phenobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may raise the metabolism of ifosfamide to its active alkylating metabolites.
Phenobarbital is actually a barbituric acid spinoff for oral administration and happens as being a white, odorless, marginally bitter powder that is soluble in chloroform, freely soluble in Alcoholic beverages or ether, and a bit soluble in water.
Corticosteroids. Barbiturates seem to improve the metabolism of exogenous corticosteroids, possibly with the induction of hepatic microsomal enzymes.
Treatment method Typical management must include symptomatic and supportive therapy, which include gastric lavage, administration of intravenous fluids, and maintenance of blood pressure, entire body temperature and satisfactory respiratory exchange.
Barbiturates tend not to impair typical hepatic perform but happen to be revealed to induce liver microsomal enzymes, Hence escalating and/or altering the metabolism of barbiturates along with other medication (see Safety measures - Drug Interactions).
Regulatory Approvals: Using non-human primates in research includes ethical criteria and involves adherence to regulatory rules for moral remedy and us
Recommend patients to use an alternative technique of contraception or perhaps a back-up strategy during coadministration, and to carry on again-up contraception for 28 days soon after discontinuing the sturdy CYP3A4 inducer to make certain contraceptive trustworthiness
Liver microsomes are in essence subcellular particles, which happen to be isolated from hepatic cells' ER organelles and are mainly placed on carry out metabolite identification, response phenotyping, intrinsic clearance, and inhibition research.
Barbiturates are weak acids which are absorbed and speedily dispersed to all tissues and fluids, with superior concentrations in the brain, liver, and kidneys. Lipid solubility from the barbiturates would get more info be the dominant Consider their distribution inside the human body.
This product may have inactive ingredients, which might result in allergic reactions or other challenges. Discuss with your pharmacist For additional aspects.
Phenobarbital has been Employed in the remedy and prophylaxis of febrile seizures. Even so, it has not been set up that prevention of febrile seizures influences the next advancement of epilepsy.
Caution ought to be exercised when phenobarbital is administered to some nursing woman, for the reason that small quantities of barbiturates are excreted in the milk.
Contraindicated (one)phenobarbital will decrease the level or influence of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with phenobarbital might cause lack of therapeutic effect and growth of resistance to darunavir
The systemic outcomes of exogenous and endogenous corticosteroids can be diminished by phenobarbital. Consequently, this merchandise must be administered with caution to people with borderline hypoadrenal operate, regardless of whether it is of pituitary or of Key adrenal origin.